- Dr Peter B. Marschik Photo INSTITUT FÜR PHYSIOLOGIE
Parental reports on early language and motor milestone in fragile X syndrome with and without autism spectrum dirorders
Methods: We retrospectively examined parental report of age of onset for walking and first words for primarily boys with FXS, both with ASD (FXS?+?ASD) and FXS-only. The diagnosis of ASD was established by DSM-IV criteria, which were complemented by the ADOS. The age of onset was analyzed as a continuous and categorical variable, which were compared to the upper limit of typically developing children.
Results: Individuals with FXS-only are more delayed in the onset of first words than first walks. The finding represents a pattern suggesting a continuum as robustly demonstrated in individuals with FXS?+?ASD vs. FXS-only.
Conclusion: Our results support validity of FXS?+?ASD co-morbidity as a distinct phenotype in individuals with FXS.
*Correspondence: Dr. Peter B. Marschik, MPhil PhD DMSc, Institute of Physiology, Center for Physiological Medicine, Medical University of Graz, Harrachgasse 21/5, 8010 Graz, Austria, 433163807629, 433163809630 firstname.lastname@example.org
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